Vitamin D supplementation improves glucose metabolism and lipid concentrations in women with gestational diabetes
At a Glance
A new study published online shows that vitamin D supplementation improves metabolic health in pregnant women with gestational diabetes.
Read more about this research below.
It is estimated that gestational diabetes, a metabolic disorder than can affect the health of both the mother and infant, affects approximately 18% of pregnancies. In a new study published online in the American Journal of Clinical Nutrition researchers analyzed the potential benefits of vitamin D supplementation on metabolic health in pregnant women with gestational diabetes.
The randomized, double-blind placebo-controlled study included 54 women with gestational diabetes. The women were randomly assigned to receive either a Vitamin D supplement containing 50,000 IU of vitamin D3 or a placebo twice during the study, once at baseline and again at day 21. Fasting blood samples were taken at the beginning and after 6 weeks. Blood samples were used measure glucose and insulin levels, insulin sensitivity and to assess markers of inflammation, and oxidative stress.
Vitamin D supplementation resulted in a significant increase in serum vitamin D levels compared to placebo. When compared to the placebo group, supplementation also resulted in significant reductions in fasting glucose and insulin, and a significant improvement in measurements of insulin sensitivity. The supplemented group also experienced a reduction in total and LDL cholesterol levels compared to the placebo group. There was no significant difference between the groups when analyzing markers of oxidation and inflammation.
The results of this study indicate that vitamin D supplementation has a beneficial effect on measures of glucose and insulin health, as well as blood lipid profiles in pregnant women with the gestational diabetes.
Zatollah Asemi et al. Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial. First published October 16, 2013, doi: 10.3945/ajcn.113.072785
At a Glance
A new study in adults over 65 has found that people with higher intakes of long-chain fatty acids, like those found in fatty fish, have a lower prevalence of subclinical brain damage and better overall brain health.
Read more about this research below.
Previous research has shown that consumption of tuna or other broiled fatty fish may be associated with fewer sub-clinical brain abnormalities.
In a new study published in the Journal of the American Heart Association, researchers investigated the association between plasma phospholipid omega-3 polyunsaturated fatty acids (PUFAs) and biomarkers of brain health using magnetic resonance imaging (MRI). Silent infarcts, which are small brain lesions caused by lack of blood flow, are associated with a decrease in thinking skills and are estimated to affect approximately 20% of healthy older individuals.
The present study included participants aged 65 and over that were part of the Cardiovascular Health Study who were analyzed by MRI between 1992 and 1994. Plasma samples from 1992 and 1993 were collected and analyzed for PUFA levels. Of this group, 2,313 adults underwent another scan after 5 years. Those with incomplete fatty acid data or who had a history of stroke were excluded from the study.
Measured by MRI, the subjects with EPA, DHA, and DPA levels in the highest 25% had a 40% lower risk of subclinical infarcts compared to participants whose levels were in the lowest 25%. The group with the lowest levels of PUFAs also had more white matter changes that those in the highest group.
The results of this study support the benefits of fish intake on brain health. Older adults with high PUFA levels may have a reduced risk of subclinical infarcts and better white matter and brain health compared to adults with low intake of long-chain polyunsaturated fatty acids.
Jyrki K. Virtanen, PhD et al. Circulating Omega-3 Polyunsaturated Fatty Acids and Subclinical Brain Abnormalities on MRI in Older Adults: The Cardiovascular Health Study. J Am Heart Assoc. 2013; 2: e000305.
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